" /> Tarlatamab - CISMeF





Preferred Label : Tarlatamab;

NCIt synonyms : DLL3/CD3-directed Bispecific T-cell Engager Antibody AMG 757; Bispecific T-cell Engager Antibody AMG 757; BiTE Antibody AMG 757; Anti-DLL3 x Anti-CD3 BiTE AMG 757; Tarlatamab-dlle;

NCIt definition : A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, tarlatamab binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen found on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.;

UNII : 74X82ST8Q1;

CAS number : 2307488-83-9;

Drug name : Imdelltra;

Molecule name : AMG-757; AMG 757;

NCI Metathesaurus CUI : CL545042;

Codes from synonyms : 136303;

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07/05/2025


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