Preferred Label : Paltusotine;
NCIt definition : An orally bioavailable, nonpeptide somatostatin receptor type 2 (SST2; SSTR2) agonist,
with potential growth hormone (GH) secretion-inhibiting and antineoplastic activities.
Upon oral administration, paltusotine targets, binds to and activates SSTR2, which
leads to an inhibition in the secretion of human growth hormone (hGH) in the pituitary
gland and results in decreased production of insulin-like growth factor (IGF-1). This
may inhibit IGF-1-mediated cell signaling pathways, and lead to apoptosis. SSTR2 is
overexpressed by some neuroendocrine tumor cells, and GH is over-produced in the pituitary
gland in acromegaly.;
UNII : F2IBD1GMD3;
InChIKey : GHILNKWBALQPDP-UHFFFAOYSA-N;
CAS number : 2172870-89-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2172870-89-0
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G-SRS /a ;
Molecule name : CRN-00808; CRN 00808;
NCI Metathesaurus CUI : CL1413248;
Origin ID : C175836;
UMLS CUI : C5432234;
Semantic type(s)
- concept_is_in_subset
- has_target
