Preferred Label : Avipendekin Pegol;
NCIt synonyms : IL-15 Receptor Agonist NKTR-255; Long-acting Polymer-engineered IL-15 Conjugate NKTR-255;
NCIt definition : A long-acting formulation composed of the human cytokine interleukin-15 (IL-15) that
is conjugated by polymers, with potential immunomodulating and anti-tumor activities.
Upon administration of avipendekin pegol, the IL-15 moiety targets and binds to the
alpha subunit of the IL-15 receptor on natural killer (NK) and T-cells, thereby activating
the IL-15-mediated pathway. This leads to the expansion and activation of natural
killer (NK) cells and memory CD8 T-cells, thereby enhancing the anti-tumor activity
of NKs and long-term memory T-lymphocyte immune responses. This may increase tumor
cell killing and decrease tumor cell proliferation. In addition, NKTR-255 may, when
combined with a tumor-directed antibody, enhance the antibody-dependent cell-mediated
cytotoxicity (ADCC) mechanism. IL-15 is a pro-inflammatory cytokine that plays a key
role in the regulation of T- and NK cell activation, proliferation and promotion of
their anti-tumor effects. Compared to IL-15 alone, the polymer formulation allows
for increased retention at the tumor site and reduced clearance, thereby increasing
the effect of IL-15.;
UNII : K25K2Y6N8C;
CAS number : 2361317-09-9;
Molecule name : NKTR 255; NKTR-255;
NCI Metathesaurus CUI : CL1413211;
Origin ID : C175746;
UMLS CUI : C5446708;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
