Preferred Label : Tinlorafenib;
NCIt synonyms : N-(2-chloro-3-((3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)-4-fluorophenyl)-3-fluoropropane-1-sulfonamide; 1-Propanesulfonamide, N-(2-chloro-3-((3,4-dihydro-3,5-dimethyl-4-oxo-6-quinazolinyl)amino)-4-fluorophenyl)-3-fluoro-; BRAF Inhibitor PF-07284890;
NCIt definition : An inhibitor of the BRAF (B-raf) protein, with potential antineoplastic activity.
Upon administration, tinlorafenib selectively targets, binds to and inhibits the activity
of BRAF, which may inhibit the proliferation of tumor cells expressing a mutated BRAF
gene. BRAF, a serine/threonine protein kinase, plays a key role in regulating the
MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF
gene mutations. Tinlorafenib may penetrate the blood-brain-barrier (BBB).;
UNII : JNJ5N2RH5W;
CAS number : 2573781-75-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2573781-75-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : PF 07284890; ARRY-461; ARRY 461; PF-07284890; AR00504461;
NCI Metathesaurus CUI : CL1413024;
Origin ID : C175553;
UMLS CUI : C5706580;
Semantic type(s)
- concept_is_in_subset
- has_target
