Preferred Label : Zirconium Zr 89-DFO-fianlimab;
NCIt synonyms : 89Zr-DFO-fianlimab; 89Zr-DFO-REGN3767;
NCIt definition : A radioimmunoconjugate consisting of fianlimab, a human monoclonal antibody directed
against the inhibitory receptor lymphocyte activation gene-3 protein (LAG-3; LAG3;
CD223), linked, via the chelator desferrioxamine (DFO), to the positron-emitting radionuclide
zirconium Zr 89 (Zr89), with potential use as an imaging agent upon positron emission
tomography (PET) imaging. Upon administration of zirconium Zr 89-DFO- fianlimab, the
fianlimab moiety specifically targets and binds to LAG-3. Upon binding, the radioisotope
moiety may be detected using PET, thereby allowing the imaging and quantification
of LAG-3-expressing tumor infiltrating lymphocytes (TILs). LAG-3, a member of the
immunoglobulin superfamily (IgSF), is expressed on various immune cells; its expression
on TILs is associated with tumor-mediated immune suppression and the negative regulation
of both cellular proliferation and T-cell activation.;
NCI Metathesaurus CUI : CL1412900;
Origin ID : C175528;
UMLS CUI : C5446595;
Semantic type(s)
- concept_is_in_subset
- has_target
