Preferred Label : FAP/4-1BB-targeting Fusion Protein RO7122290;
NCIt definition : A bispecific antibody-like fusion protein consisting of a trimeric ligand for the
T-cell co-stimulatory immune receptor 4-1BB (CD137; tumor necrosis factor receptor
superfamily member 9; TNFRSF9) and an antigen-binding fragment (Fab) moiety targeting
the tumor-associated protein fibroblast activation protein (FAP), with potential immunomodulating
and antineoplastic activities. Upon administration, the FAP/4-1BB-targeting fusion
protein RO7122290 targets and binds to both FAP, localized on tumor stromal cells,
and 4-1BB, expressed on a variety of leukocyte subsets including activated T-lymphocytes
and natural killer (NK) cells. The simultaneous binding of FAP and 4-1BB results in
local clustering of FAP-expressing tumor stromal cells and 4-1BB-expressing T-cells,
and local immune cell activation through the promotion of T-cell activation, cytokine
release and T-cell-mediated anti-tumor immune responses. 4-1BB, a surface glycoprotein
of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor
that plays a key role in T-cell proliferation, survival and cytolytic activity. FAP
is abundantly expressed by cancer-associated fibroblasts in the majority of solid
tumors.;
Molecule name : RO 7122290; RO-7122290;
NCI Metathesaurus CUI : CL1412832;
Origin ID : C175490;
UMLS CUI : C5446567;
Semantic type(s)
- concept_is_in_subset
- has_target
