Preferred Label : Anti-CCR7 Antibody-drug Conjugate JBH492;
NCIt synonyms : Anti-CCR7 ADC JBH492; Anti-CCR7-DM4 Antibody-drug Conjugate JBH492;
NCIt definition : An antibody-drug conjugate (ADC) composed of an antibody targeting CC chemokine receptor
7 (CCR7) and conjugated to the cytotoxic maytansinoid DM4, with potential antineoplastic
activity. Upon administration of anti-CCR7 ADC JBH492, the antibody moiety targets
and binds to CCR7 on tumor cells. Upon antibody/antigen binding and internalization,
the ADC releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly
dynamics. This results in the inhibition of cell division and cell growth of CCR7-expressing
tumor cells. CCR7, a G-protein coupled receptor, is normally expressed by subsets
of immune cells and overexpressed by various types of cancer cells. Its overexpression
has been associated with lymph node metastasis and poor survival.;
Molecule name : JBH 492; JBH-492;
NCI Metathesaurus CUI : CL1412845;
Origin ID : C175477;
UMLS CUI : C5446557;
Semantic type(s)
- concept_is_in_subset
- has_target
