Preferred Label : Copper Cu 64-DOTA-pembrolizumab;
NCIt synonyms : 64Cu-pembrolizumab; Copper Cu 64 Pembrolizumab; 64Cu-DOTA-pembrolizumab; 64Cu-labeled Pembrolizumab;
NCIt definition : A radioimmunoconjugate composed of pembrolizumab, a humanized monoclonal immunoglobulin
(Ig) G4 antibody directed against the human cell surface receptor programmed cell
death 1 (PD-1; PDCD1; CD279; programmed cell death-1), conjugated with the bifunctional,
macrocyclic chelating agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic
acid (DOTA) and labeled with the radioisotope copper Cu 64, with potential diagnostic
properties upon positron emission tomography (PET) imaging. Upon administration, the
monoclonal antibody moiety of copper Cu 64-DOTA-pembrolizumab specifically binds to
PD-1, an inhibitory signaling receptor expressed on the surface of activated T-cells,
and blocks the binding to and activation of PD-1 by its ligands. Upon PET imaging,
PD-1-expressing T-cells, as well as pembrolizumab biodistribution, can be visualized
and the expected response to treatment with pembrolizumab, as well as selection of
patients that would respond to pembrolizumab, can be assessed. The ligands for PD-1
include programmed cell death-1 ligand 1 (PD-L1), which is overexpressed on certain
cancer cells, and programmed cell death-1 ligand 2 (PD-L2), which is primarily expressed
on antigen-presenting cells (APCs). Activated PD-1 negatively regulates T-cell activation
and plays a key role in tumor evasion from host immunity.;
NCI Metathesaurus CUI : CL1412691;
Origin ID : C175389;
UMLS CUI : C5446484;
Semantic type(s)
- concept_is_in_subset
- has_target
