Cilgavimab/Tixagevimab

Preferred Label : Cilgavimab/Tixagevimab;

NCIt synonyms : Monoclonal Antibody AZD7442; AZD8895 AZD1061; Anti-SARS-CoV-2 Spike Protein Monoclonal Antibody AZD7442; AZD8895/AZD1061;

NCIt related terms : Monoclonal antibodies against SARS-CoV-2: tixagevimab/cilgavimab;

NCIt definition : A combination of two neutralizing human monoclonal antibodies cilgavimab and tixagevimab, that are isolated from convalescent patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, and directed against the spike (S) protein, that can potentially be used for passive immunization against Coronavirus disease 2019 (COVID-19). Upon administration of cilgavimab/tixagevimab, both antibodies specifically target and bind to the SARS-CoV-2 S protein, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. S protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.;

Drug name : Evusheld;

Molecule name : AZD 7442; AZD-7442;

NCI Metathesaurus CUI : CL1412606;

Origin ID

C175229;

UMLS CUI

C5564078;

Currated CISMeF NLP mapping
- cilgavimab and tixagevimab drug combination [MeSH Supplementary Concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tixagevimab and cilgavimab [ATC Code]
Validated automatic mappings to BTNT
- tixagevimab and cilgavimab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- ACC/AHA COVID-19 Appendix Variables [NCIt concept]
- ACC/AHA Cardiovascular and Noncardiovascular Complications of COVID-19 Terminology [NCIt concept]
- Appendix 8: Pharmacological Therapy Terminology [NCIt concept]
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
- Therapies for COVID-19 Terminology [NCIt concept]

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