Acylamino-Acid-Releasing Enzyme

Preferred Label : Acylamino-Acid-Releasing Enzyme;

NCIt synonyms : N-formylmethionine aminopeptidase; ACPH; APEH; APH Protein; EC 3.4.19.1; Acylpeptide Hydrolase; AARE; Acylaminoacyl-Peptidase;

NCIt definition : Acylamino-acid-releasing enzyme (732 aa, 81 kDa) is encoded by the human APEH gene. This protein plays a role in aminopeptidase activity.;

NCIt note : Acylamino-acid-releasing enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. (UniProt);

NCI Metathesaurus CUI : CL790893;

Details

Origin ID

C17472;

UMLS CUI

C4548799;

Currated CISMeF NLP mapping
- Acylamino-acid-releasing enzyme (substance) [SNOMED CT concept]
- N-formylmethionine aminopeptidase [MeSH concept]
- N-formylmethionine aminopeptidase [MeSH Supplementary Concept]
- acylamino-acid-releasing enzyme [SNOMED Notion]
- acylaminoacyl-peptidase [MeSH concept]
False automatic mappings
- acylaminoacyl-peptidase [MeSH Supplementary Concept]
OMIM relation
- Acylaminoacyl-peptide hydrolase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- APEH protein, human [MeSH Supplementary Concept]
- Acylamino-acid-releasing enzyme (substance) [SNOMED CT concept]
- acylamino-acid-releasing enzyme [SNOMED Notion]
- acylaminoacyl-peptidase [MeSH concept]
- acylaminoacyl-peptidase [MeSH Supplementary Concept]
gene_encodes_gene_product
- APEH Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Lung [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Lung Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Peptide Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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