NCIt definition : A monoclonal antibody directed against the immune inhibitory receptor leukocyte immunoglobulin-like
receptor B4 (LILRB4), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration, anti-LILRB4 monoclonal antibody IO-202 targets, binds
to and inhibits LILRB4 and its downstream signaling pathways. This may restore immune
function through the activation of T-cells and T-cell-mediated immune responses against
tumor cells, and inhibit tumor infiltration. LILRB4, an immune inhibitory receptor
normally expressed on monocytic cells and highly expressed on monocytic acute myeloid
leukemia (AML) cells, functions as an immune checkpoint that negatively regulates
T-cell activation as its extracellular domain inhibits T-cell activity. It plays an
important role in tumor infiltration in leukemias through multiple signaling pathways.;
Semantic type(s)