Preferred Label : Copper Cu 64 Ucasareotide Dasaroxetan;
NCIt synonyms : Copper Cu 64-SARTATE; Cu-64 SARTATE; 64Cu-SARTATE; Copper 64 SARTATE; 64Cu-labeled MeCOSar-Tyr3-octreotate; Copper Cu 64-MeCOSar-Tyr3-octreotate;
NCIt related terms : UCASAREOTIDE DASAROXETAN CU-64;
NCIt definition : A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate
(TATE) conjugated with the bifunctional chelator 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic
acid (MeCOSar) and labeled with the positron emission tomography (PET) tracer copper
Cu 64, which may be used to image somatostatin receptor (SSTR)-expressing neuroendocrine
tumors (NETs) upon PET. Upon administration of copper Cu 64 ucasareotide dasaroxetan,
the TATE moiety targets and binds to SSTRs, with high affinity for type 2 SSTR, present
on the cell membranes of many types of NETs. This allows for visualization of SSTR-positive
tumor cells upon PET. TATE is an octreotide derivative in which phenylalanine at position
3 is substituted by tyrosine and position 8 threoninol is replaced with threonine.
SSTRs have been shown to be present in large numbers on NETs and their metastases,
while most other normal tissues express low levels of SSTRs.;
UNII : UJY48W6ADC;
NCI Metathesaurus CUI : CL1412004;
Origin ID : C174469;
UMLS CUI : C5391556;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
