Preferred Label : Anti-CD4 CAR T-cells;
NCIt synonyms : CD4 CAR T Cells; CD4-specific CAR T Cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified and transduced
with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the
tumor-associated antigen (TAA) CD4 and containing, as of yet undisclosed co-stimulatory
signaling domains, with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CD4 CAR T-cells target and bind to CD4-expressing tumor
cells, thereby inducing selective toxicity in CD4-expressing tumor cells. CD4 antigen
is expressed in CD4-positive T cell lymphomas.;
NCI Metathesaurus CUI : CL1411978;
Origin ID : C174420;
UMLS CUI : C5420769;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
