Preferred Label : BTK Inhibitor HZ-A-018;
NCIt synonyms : Bruton's Tyrosine Kinase Inhibitor HZ-A-018;
NCIt definition : An orally bioavailable inhibitor of Bruton's tyrosine kinase (BTK), with potential
antineoplastic activity. Upon administration, BTK inhibitor HZ-A-018 targets, binds
to and inhibits the activity of BTK and prevents the activation of the B-cell antigen
receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated
activation of downstream survival pathways. This leads to an inhibition of the growth
of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec
family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it
plays an important role in B lymphocyte development, activation, signaling, proliferation
and survival.;
Molecule name : HZ-A-018; HZ-A 018;
NCI Metathesaurus CUI : CL1411950;
Origin ID : C174394;
UMLS CUI : C5418081;
Semantic type(s)
- concept_is_in_subset
- has_target
