Preferred Label : Latikafusp;
NCIt synonyms : Anti-PD-1 Antibody-IL-21 Mutein Fusion Protein AMG 256; PD-1-targeted IL-21 Receptor Agonist AMG 256; Anti-PD-1 Antibody-interleukin-21 Mutein Fusion Protein AMG 256;
NCIt definition : An antibody directed against the negative immunoregulatory human cell receptor programmed
cell death protein 1 (PD-1; PDCD1; CD279) fused to a mutein of the cytokine interleukin-21
(IL-21), with potential immune checkpoint inhibitory, immunomodulating and antineoplastic
activities. Upon administration of latikafusp, the antibody moiety specifically targets,
binds to and inhibits PD-1 and its downstream signaling pathways. This may restore
immune function through the activation of T-cells and T-cell-mediated immune responses
against tumor cells. The IL-21 mutein moiety binds to the IL-21 receptor and activates
IL-21 cytokine signaling in PD-1-expressing cells. This may modulate the proliferation
and/or differentiation, promote survival, and increase the cytolytic activity of PD-1-expressing
T-cells, thereby enhancing T-cell-mediated immune responses against tumor cells. PD-1,
a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells,
functions as an immune checkpoint that negatively regulates T-cell activation and
effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1;
cluster of differentiation 274; CD274) or 2 (PD-L2); it plays an important role in
tumor evasion from host immunity. IL-21 plays an important role in the regulation
of cellular immune responses.;
UNII : F188ZI78F7;
CAS number : 2552814-07-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2552814-07-8
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G-SRS /a ;
Molecule name : AMG-256; AMG 256;
NCI Metathesaurus CUI : CL1407782;
Origin ID : C174140;
UMLS CUI : C5706688;
Semantic type(s)
- concept_is_in_subset
- has_target
