B-Cell Differentiation Antigen CD72

Preferred Label : B-Cell Differentiation Antigen CD72;

NCIt synonyms : LYB2; CD72; CD72 Antigen; CD100 Receptor; Mouse Homolog LYB2; Lyb-2;

NCIt definition : B-cell differentiation antigen CD72 (359 aa, 40 kDa) is encoded by the human CD72 gene. This protein plays a role in the proliferation and differentiation of B-cells.;

NCIt note : Expression of CD72 is restricted to B-lineage cells and is turned off in differentiated antibody-secreting plasma cells. CD72 may participate in signals for B-cell proliferation and differentiation. In the immune system, CD72 appears to be a receptor for leukocyte activation antigen, CD100. CD72 may also be the ligand for CD5, a receptor that regulates T-cell proliferation.;

Details

Origin ID

C17404;

UMLS CUI

C0081944;

OMIM relation
- Cd72 antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- CD72 [LOINC component]
- CD72 protein, human [MeSH concept]
- CD72 protein, human [MeSH Supplementary Concept]
- Lymphocyte antigen CD72 (substance) [SNOMED CT concept]
- lymphocyte antigen cd72 [SNOMED Notion]
gene_encodes_gene_product
- CD72 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- B-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Phosphoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Immune Response Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients