Preferred Label : Dargistotug;
NCIt synonyms : TIGIT Inhibitor M6223;
NCIt definition : An inhibitor of T-cell immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory
motif (ITIM) domains (TIGIT), a co-inhibitory molecule and immune checkpoint inhibitor,
with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,
dargistotug targets and binds to TIGIT expressed on various immune cells, particularly
on tumor-infiltrating T-lymphocytes (TILs), thereby preventing the interaction of
TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2)
and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5). This enhances
the interaction of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory
molecule-1; DNAM-1), which is expressed on immune cells, such as natural killer (NK)
cells and CD8 T-cells. This leads to CD226 dimerization and CD226-mediated signaling
and activates the immune system to exert a T-cell-mediated immune response against
cancer cells. TIGIT, a member of the Ig super family (IgSF) and an immune inhibitory
receptor, plays a key role in the suppression of T-cell proliferation and activation;
it is involved in tumor cell immune evasion, and the inhibition of antiviral immune
responses.;
UNII : 4O3LRM3I5J;
CAS number : 2649362-29-6;
Molecule name : M-6223; M 6223;
NCI Metathesaurus CUI : CL1407689;
Origin ID : C173891;
UMLS CUI : C5708892;
Semantic type(s)
- concept_is_in_subset
- has_target
