Antibody-Dependent Enhancement of Infection

Preferred Label : Antibody-Dependent Enhancement of Infection;

NCIt synonyms : Antibody-Dependent Enhancement;

NCIt definition : A phenomenon that occurs when antibodies present in the body from a primary infection bind to an infecting viral particle during a subsequent infection with a different serotype. The antibodies from the primary infection cannot neutralize the virus. Instead, the Ab-virus complexes attach to Fc receptors on circulating monocytes. The antibodies then facilitate more efficient viral infection of monocytes. The outcome is an increase in the overall replication of the virus and a higher risk of disease that is more severe than the initial infection.;

Details

Origin ID

C173774;

UMLS CUI

C0282632;

Automatic exact mappings (from CISMeF team)
- infection-associated enhanced disease [COVID-19 Thesaurus concept]
Currated CISMeF NLP mapping
- Antibody-Dependent enhancement [MeSH concept]
- Antibody-dependent enhancement [MedDRA Preferred Term]
- antibody-dependent enhancement [MeSH Descriptor]
Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
UMLS correspondences (same concept)
- Antibody-Dependent enhancement [MeSH concept]
- Antibody-dependent enhancement [MedDRA Preferred Term]
- antibody-dependent enhancement [MeSH Descriptor]
biological_process_has_initiator_chemical_or_drug
- Antigen [NCIt concept]
biological_process_is_part_of_process
- Immunity [NCIt concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients