Preferred Label : infection-associated enhanced disease;
Definition : Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement
or disease enhancement, is a phenomenon in which binding of a virus to suboptimal
antibodies enhances its entry into host cells, followed by its replication. Antiviral
antibodies promote viral infection of target immune cells by exploiting the phagocytic
FcγR or complement pathway. After interaction with the virus the antibody binds Fc
receptors (FcR) expressed on certain immune cells or some of the complement proteins.
(Wikipédia);
Synonyme : antibody-dependent enhancement;
Origin ID : GGJVKFJT-9;
Automatic exact mappings (from CISMeF team)
Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement
or disease enhancement, is a phenomenon in which binding of a virus to suboptimal
antibodies enhances its entry into host cells, followed by its replication. Antiviral
antibodies promote viral infection of target immune cells by exploiting the phagocytic
FcγR or complement pathway. After interaction with the virus the antibody binds Fc
receptors (FcR) expressed on certain immune cells or some of the complement proteins.
(Wikipédia)
