NCIt definition : An antisense oligonucleotide (ASO) targeting the interferon regulatory factor 4 (IRF4)
mRNA, with potential immunomodulating and antineoplastic activities. Upon intravenous
administration, frenlosirsen hybridizes with IRF4 mRNA, which blocks translation of
the IRF4 protein. Reduction of IRF4 levels prevents the expression of IRF4-controlled
tumor promoter genes, and may enhance tumor cell apoptosis and prevent T-cell exhaustion.
IRF4, a transcription factor expressed in lymphocytes and essential for plasma cell
differentiation, is involved in immune cell development and plays a key role in T-cell
functions. It is overexpressed in certain tumor cell types and is a key regulator
of multiple genes controlling tumor cell survival.;
Semantic type(s)