Ginisortamab - CISMeF

Preferred Label : Ginisortamab;

NCIt synonyms : Anti-GREM1 Monoclonal Antibody UCB6114; Anti-gremlin-1 Monoclonal Antibody UCB6114;

NCIt definition : A monoclonal antibody directed against gremlin-1 (GREM1; Drm), with potential antineoplastic activity. Upon administration, ginisortamab specifically targets and binds to gremlin-1, thereby neutralizing Gremlin-1. This may block the gremlin-1-mediated inhibition of bone morphogenetic protein (BMP) signaling pathways, and may lead to the inhibition of tumor cell growth and proliferation. Gremlin-1, a BMP antagonist that is overexpressed in a variety of cancer cell types, is involved in cancer cell growth and proliferation as well as tissue fibrosis.;

UNII : 6808SG2XRK;

CAS number : 2390147-17-6;

Molecule name : UCB-6114; UCB 6114;

NCI Metathesaurus CUI : CL1407518;

Details

Origin ID

C173701;

UMLS CUI

C5667207;

Currated CISMeF NLP mapping
- Ginisortamab [SMS substance]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Gremlin-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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