NCIt definition : A monoclonal antibody directed against gremlin-1 (GREM1; Drm), with potential antineoplastic
activity. Upon administration, ginisortamab specifically targets and binds to gremlin-1,
thereby neutralizing Gremlin-1. This may block the gremlin-1-mediated inhibition of
bone morphogenetic protein (BMP) signaling pathways, and may lead to the inhibition
of tumor cell growth and proliferation. Gremlin-1, a BMP antagonist that is overexpressed
in a variety of cancer cell types, is involved in cancer cell growth and proliferation
as well as tissue fibrosis.;
UNII : 6808SG2XRK;
CAS number : 2390147-17-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2390147-17-6
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G-SRS /a ;
Semantic type(s)