NCIt definition : A nonfucosylated human immunoglobulin G1 (IgG1) monoclonal antibody targeting the
co-inhibitory molecule and immune checkpoint inhibitor T-cell immunoreceptor with
immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains
(TIGIT), with potential immune checkpoint inhibitory activity. Upon administration,
anti-TIGIT monoclonal antibody SGN-TGT targets and binds to TIGIT expressed on various
immune cells, particularly on tumor-infiltrating T-lymphocytes (TILs). This prevents
the interaction of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2;
PRR2; PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5),
and enhances the interaction of CD112 and CD155 with the costimulatory receptor CD226
(DNAX Accessory molecule-1; DNAM-1), which is expressed on immune cells, such as natural
killer (NK) cells and CD8 T-cells. This enhances depletion of TIGIT-positive regulatory
T-cells (Tregs) and activates the immune system to exert a T-cell-mediated immune
response against cancer cells. TIGIT, a member of the Ig super family (IgSF) and an
immune inhibitory receptor, plays a key role in the suppression of T-cell proliferation
and activation; it is involved in tumor cell immune evasion, and the inhibition of
antiviral immune responses.;
Molecule name : SGN-TGT; SGN TGT; SEA-TGT; SEA TGT;
Semantic type(s)