NCIt synonyms : Heat Shock Protein 90 Inhibitor TQB3474;
NCIt definition : An inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic activity.
Upon administration, Hsp90 inhibitor TQB3474 specifically blocks Hsp90, which inhibits
its chaperone function and promotes the proteasomal degradation of oncogenic signaling
proteins involved in tumor cell proliferation and survival. This may lead to an inhibition
of tumor cell proliferation. Hsp90, a chaperone complex protein upregulated in a variety
of tumor cell types, regulates the folding and degradation of many oncogenic signaling
proteins.;
Semantic type(s)