Preferred Label : Bcl-2 Inhibitor LP-108;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
Bcl-2 inhibitor LP-108 targets, binds to and inhibits the activity of Bcl-2. This
restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers
and plays an important role in the negative regulation of apoptosis; its expression
is associated with increased drug resistance and tumor cell survival.;
Molecule name : LP-108; LP 108;
NCI Metathesaurus CUI : CL1407495;
Origin ID : C173536;
UMLS CUI : C5417991;
- Semantic type(s)
- concept_is_in_subset
- has_target