Preferred Label : Copper Cu 64 Dotatate;
NCIt synonyms : 64Cu-DOTATATE; 64Cu-DOTA-TATE; Copper Cu 64 Oxodotreotide;
NCIt related terms : COPPER OXODOTREOTIDE CU-64;
NCIt definition : A radioconjugate consisting of the somatostatin analog tyrosine-3-octreotate (Tyr3-octreotate
or TATE) labeled, via the macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic
acid (DOTA), with the positron emission tomography (PET) tracer copper Cu 64, which
may be used to image somatostatin receptor (SSTR)-expressing neuroendocrine tumors
(NETs) upon PET. Upon administration of copper Cu 64 Dotatate, the TATE moiety targets
and binds to SSTRs, with a much higher affinity for type 2 SSTR, present on the cell
membranes of many types of NETs. This allows for visualization of SSTR-positive tumor
cells upon PET. SSTR subtypes have been shown to be present in large numbers on NETs
and their metastases, while most other normal tissues express low levels of SSTR subtypes.;
UNII : N3858377KC;
CAS number : 1426155-87-4;
NCI Metathesaurus CUI : CL1407514;
Origin ID : C173524;
UMLS CUI : C3502191;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
