Preferred Label : EP4 Antagonist INV-1120;
NCIt synonyms : EP4 Receptor Antagonist INV-1120; Prostaglandin E2 Receptor Antagonist INV-1120; PGE2 Receptor Antagonist INV-1120;
NCIt definition : A small molecule and antagonist of the prostaglandin E2 receptor subtype 4 (PTGER4;
EP4), with potential immunomodulating and antineoplastic activities. Upon administration,
the EP4 antagonist INV-1120 selectively targets and binds to EP4, inhibiting the binding
of the immunosuppressive prostaglandin E2 (PGE2) to EP4. This prevents the activation
of EP4 and inhibits PGE2-EP4-mediated signaling, thereby inhibiting proliferation
of tumor cells in which the PGE2-EP4 signaling pathway is over-activated. In addition,
EP4 inhibition prevents the activity of tumor-associated myeloid cells (TAMCs) in
the tumor microenvironment (TME) by inhibiting interleukin-23 (IL-23) production and
the IL-23-mediated expansion of Th17 cells. EP4, a prostanoid receptor, is a G protein-coupled
receptor that is expressed in certain types of cancers; it promotes tumor cell proliferation
and invasion.;
Molecule name : INV-1120; INV 1120;
NCI Metathesaurus CUI : CL1407506;
Origin ID : C173520;
UMLS CUI : C5417989;
Semantic type(s)
- concept_is_in_subset
- has_target
