NCIt definition : A recombinant immunoglobulin G1 (IgG1) bispecific antibody targeting both the human
T-cell surface antigen CD3 and oncofetal antigen 5T4, with potential immunomodulating
and antineoplastic activities. Upon administration, anti-CD3/anti-5T4 bispecific antibody
GEN1044 simultaneously targets and binds to CD3 expressed on T-cells and 5T4 expressed
on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte
(CTL) response against the 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein,
is overexpressed by a variety of cancer cell types; its expression is correlated with
increased invasiveness.;
Semantic type(s)