Preferred Label : Topotecan Sustained-release Episcleral Plaque;
NCIt synonyms : Transscleral Topotecan; Sustained Release Episcleral Topotecan; Episcleral Topotecan; Topotecan SR Episcleral Plaque; Sustained-release Topotecan Episcleral Plaque; SR Topotecan Episcleral Plaque;
NCIt definition : An episcleral plaque containing sustained-release (SR) topotecan, a semisynthetic
derivative of camptothecin and a cytotoxic, quinoline-based alkaloid extracted from
the Asian tree Camptotheca acuminate, with potential antineoplastic activity. Upon
local application of the topotecan SR episcleral plaque to the eye, topotecan is released
in a sustained manner and inhibits topoisomerase I activity by stabilizing the topoisomerase
I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation
of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal
double-strand DNA breaks when encountered by the DNA replication machinery. The episcleral
plaque allows for local delivery of topotecan for the potential treatment of retinoblastoma.;
Drug name : Chemoplaque;
NCI Metathesaurus CUI : CL1407190;
Origin ID : C173363;
UMLS CUI : C5420173;
Semantic type(s)
- concept_is_in_subset
- has_target
