Preferred Label : Streptavidin;
NCIt definition : A bacterial protein that has high affinity for biotin. The non-covalent streptavidin-biotin
complex is resistant to organic solvents, denaturants, detergents, proteolytic enzymes,
and extremes in temperatures and pH. The stability of the complex is leveraged by
many research and clinical procedures including protein purification, chemiluminescent,
fluorescent and colorimetric immunostaining, atomic force microscopy, synthesis of
carbon nanotubes and DNA-based nanoparticles, and targeted immunotherapy.;
Alternative definition : NCI-GLOSS: A small bacterial protein that binds with high affinity to the vitamin
biotin. This streptavidin-biotin combination can be used to link molecules such as
radioisotopes and monoclonal antibodies together. These bound products have the property
of being attracted to, and attaching to, cancer cells, rather than normal cells. The
radiolabeled products are more easily removed from the body, thus decreasing their
toxicity.;
Codes from synonyms : CDR0000045912;
Origin ID : C17334;
UMLS CUI : C0075278;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_product_has_biochemical_function
- gene_product_has_organism_source
