Cell Surface Glycoprotein MUC18

Preferred Label : Cell Surface Glycoprotein MUC18;

NCIt synonyms : MUC18 Glycoprotein; MCAM; S-Endo; CD146 Antigen; A32; Mel-CAM; Melanoma Cell Adhesive Molecule; Melanoma Cell Adhesion Molecule; S-Endo 1 Endothelial-Associated Antigen; Melanoma-Associated Antigen A32; Cell Surface Glycoprotein P1H12; Melanoma Adhesion Molecule; Melanoma-Associated Antigen MUC18; MUC18 Antigen;

NCIt definition : Cell surface glycoprotein MUC18 (646 aa, 72 kDa) is encoded by the human MCAM gene. This protein is involved in vascular endothelial cell adhesion.;

NCIt note : Active in neural crest cells during development and expressed primarily in neuroectodermal lineages and vascular smooth muscle in adult tissues by human MCAM Gene (Ig Superfamily), 646-aa 72-kDa (precursor) Melanoma Adhesion Molecule is a cell surface type I membrane glycoprotein containing 3 Ig-like C2-type domains and 2 Ig-like V-type domains and a possible adhesion molecule homologue of cell adhesion molecule NCAM.;

UNII : GD0L57IOD9;

Details

Origin ID

C17313;

UMLS CUI

C0386212;

Automatic exact mappings (from CISMeF team)
- Melanoma adhesion molecule [OMIM gene]
- melanoma cell adhesion molecule [HGNC gene]
Currated CISMeF NLP mapping
- CD146 Antigen [MeSH Descriptor]
- CD146 Antigen [MeSH concept]
OMIM relation
- Melanoma adhesion molecule [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- MCAM protein, human [MeSH Supplementary Concept]
- MCAM protein, human [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- MCAM Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Immunoglobulin-Like V-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Morphogenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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