Tozinameran - CISMeF

Preferred Label : Tozinameran;

NCIt synonyms : BNT162b2 COVID-19 Vaccine; BNT1162b2 SARS-CoV-2 Vaccine; Pfizer-BioNTech COVID-19 Vaccine; SARS-CoV-2 SP mRNA LNP Vaccine BNT162b2; Pfizer COVID-19 Vaccine;

NCIt related terms : Pfizer/BioNTech COVID-19 Vaccine; BNT162b2 (Pfizer-BioNTech);

NCIt definition : A formulation consisting of lipid nanoparticle (LNP) encapsulating a nucleoside modified messenger RNA (modRNA) encoding an optimized form of the full-length severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunizing and anti-COVID-19 activities. Upon injection of tozinameran, the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the cell. The mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody and T-cell-mediated immune response. This may provide active immunization against SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.;

UNII : 5085ZFP6SJ;

CAS number : 2417899-77-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2417899-77-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Comirnaty;

Molecule name : BNT-162b2; BNT 162b2;

NCI Metathesaurus CUI : CL1406825;

Details

Origin ID

C173055;

UMLS CUI

C5398043;

Automatic exact mappings (from CISMeF team)
- BNT162 Vaccine [MeSH Descriptor]
- Comirnaty [COVID-19 Thesaurus concept]
CISMeF manual mappings
- NUCLEOSIDE-MODIFIED MRNA ENCODING A MODIFIED VERSION OF THE SARS-COV-2 S PROTEIN [Drug component]
Currated CISMeF NLP mapping
- Tozinameran [MeSH concept]
- Tozinameran (substance) [SNOMED CT concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BNT162 Vaccine [MeSH Descriptor]
- Tozinameran (substance) [SNOMED CT concept]
concept_is_in_subset
- ACC/AHA COVID-19 Appendix Authorized Values [NCIt concept]
- ACC/AHA Cardiovascular and Noncardiovascular Complications of COVID-19 Terminology [NCIt concept]
- Appendix 8: Pharmacological Therapy Terminology [NCIt concept]
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
- SeroNet Authorized Values [NCIt concept]
- SeroNet Study Descriptors [NCIt concept]
- Therapies for COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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