Low-dose Aldesleukin ILT-101

Preferred Label : Low-dose Aldesleukin ILT-101;

NCIt synonyms : Low-dose IL-2 ILT-101;

NCIt definition : A low-dose formulation of aldesleukin, a recombinant analog of the human endogenous cytokine interleukin-2 (IL-2), with potential immunoregulatory activity. Upon administration of low-dose aldesleukin ILT-101, this agent binds to and activates the IL-2 receptor (IL2R), thereby activating IL2R-mediated signaling. This enhances the expansion and stimulation of regulatory T cells (Tregs). This prevents excessive inflammation and autoimmunity. It also blocks the differentiation of CD4 naïve T cells into follicular helper or proinflammatory helper 17 (Th17) T cells. Tregs, a subpopulation of CD4 T cells, plays a key role in the control of immune responses and T-cell immune tolerance. Activation of IL2R with low dose IL-2 preferentially induces Tregs development and activation while activation of IL2R with high dose IL-2 induces the activation of T effector (Teff) cells.;

Molecule name : ILT 101; ILT-101;

NCI Metathesaurus CUI : CL1406857;

Details

Origin ID

C172825;

UMLS CUI

C5417947;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Interleukin-2 Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Induction [NCIt concept]
- Lymphocyte Activation Process [NCIt concept]
concept_is_in_subset
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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