" /> Photodynamic Compound TLD-1433 - CISMeF





Preferred Label : Photodynamic Compound TLD-1433;

NCIt synonyms : PDC TLD-1433;

NCIt related terms : TLD-1433;

NCIt definition : A non-toxic ruthenium-based coordination-complex and photosensitizer, with potential antineoplastic activity upon photodynamic therapy (PDT). Upon intravesical administration, light-activated photodynamic compound (PDC) TLD-1433 targets and binds to transferrin (Tf) and is subsequently taken up by Tf receptors which are located on tumor cells. Upon exposure to green light (525nm), TLD-1433 becomes activated locally and induces the generation of reactive oxygen species (ROS) and singlet oxygen. The release of free radicals may induce apoptosis and destroy the tumor cells. Cancer cells have many more Tf receptors than normal cells,;

UNII : L59D69SZN5;

CAS number : 1471479-22-7;

Molecule name : TLD-1433; TLD 1433;

NCI Metathesaurus CUI : CL1406854;

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30/07/2025


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