NCIt definition : A recombinant immunoglobulin G4 (IgG4) kappa monoclonal antibody directed against
the negative immunoregulatory human cell receptor programmed cell death protein 1
(PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration, abazistobart targets, binds to and inhibits PD-1
and its downstream signaling pathways. This may restore immune function through the
activation of T-cells and T-cell-mediated immune responses against tumor cells. PD-1,
a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells,
functions as an immune checkpoint that negatively regulates T-cell activation and
effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1)
or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.;
Semantic type(s)