NCIt definition : The hydrochloride salt form of galidesivir, an adenosine analog and RNA polymerase
inhibitor, with potential broad-spectrum antiviral activity. Upon administration,
galidesivir is metabolized to its monophosphate form, which is then converted into
the active triphosphate nucleotide. Galidesivir triphosphate binds to viral RNA-dependent
RNA polymerase (RdRp) and gets incorporated into the growing viral RNA strand, which
leads to premature chain termination. This prevents viral transcription and replication.;
Semantic type(s)