Preferred Label : Golcadomide;
NCIt synonyms : Cereblon E3 Ubiquitin Ligase Modulating Drug CC-99282; Cereblon Modulator CC-99282; CelMod CC-99282;
NCIt related terms : Cereblon E3 Ubiquitin Ligase Modulating Agent CC-99282;
NCIt definition : A modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin
ligase), with potential immunomodulating and antineoplastic activities. Upon administration,
golcadomide specifically binds to cereblon (CRBN), thereby affecting the ubiquitin
E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This
induces proteasome-mediated degradation of certain transcription factors, some of
which are transcriptional repressors in T-cells. This leads to modulation of the immune
system, including activation of T-lymphocytes, and downregulation of the activity
of other proteins, some of which play key roles in the proliferation of certain cancer
cell types. CRBN, the substrate recognition component of the CRL4-CRBN E3 ubiquitin
ligase complex, plays a key role in the ubiquitination of certain proteins.;
UNII : 29HLR8Z5BR;
CAS number : 953769-46-5;
Molecule name : CC99282; CC -99282; BMS-986369; BMS 986369;
NCI Metathesaurus CUI : CL1406350;
Origin ID : C172396;
UMLS CUI : C5706674;
Semantic type(s)
- concept_is_in_subset
- has_target
