Preferred Label : Trastuzumab Imbotolimod;
NCIt synonyms : ISAC BDC-1001; Immune Stimulating Antibody Conjugate BDC-1001; Trastuzumab-TLR 7/8 Agonist BDC-1001;
NCIt definition : An immune stimulating antibody conjugate (ISAC) consisting of trastuzumab, an anti-human
epidermal growth factor receptor 2 (HER2) monoclonal antibody, conjugated to a Toll-like
receptor (TLR) 7/8 dual agonist, with potential immunostimulating and antineoplastic
activities. Upon administration of trastuzumab imbotolimod, the trastuzumab moiety
targets and binds to HER2 expressed on tumor cells and, simultaneously, the TLR 7/8
dual agonist moiety targets, binds to and activates TLR7/8 expressed on antigen-presenting
cells (APCs), specifically dendritic cells (DCs), in the tumor microenvironment (TME).
The trastuzumab binding to the tumor cells causes the engulfment of the trastuzumab
imbotolimod-bound tumor cells by tumor-associated myeloid (TAM) cells and the TAMs
travel to the lymph nodes. The DCs activated by the TLR7/8 agonist causes the activation
of TLR7/8-mediated pathways, and stimulates the maturation and activation of DCs,
thereby re-activating the immune system against the tumor cells. Activation of DCs
results in the production of pro-inflammatory cytokines, and the activation of cytotoxic
T-lymphocyte (CTL)- and B-lymphocyte-mediated immune responses against tumor-associated
antigens (TAAs), which lead to tumor cell lysis. TLR7 and 8, members of the TLR family,
play fundamental roles in the activation of the innate immune system, myeloid cell
responses and tumor antigen presentation. HER2 is overexpressed by a variety of tumor
cell types.;
UNII : LNG8RG3NMF;
CAS number : 2643926-85-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2643926-85-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : BDC-1001; BDC 1001;
NCI Metathesaurus CUI : CL1406514;
Origin ID : C172388;
UMLS CUI : C5708891;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
