Transformation

Preferred Label : Transformation;

NCIt synonyms : Cellular Transformation; Cell Transformation; Transformed; Transforming;

NCIt definition : The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events.;

Alternative definition : NCI-GLOSS: In medicine, the change that a normal cell undergoes as it becomes malignant.;

Codes from synonyms : CDR0000046628;

Details

Origin ID

C17212;

UMLS CUI

C1510411;

Automatic exact mappings (from CISMeF team)
- No transformation (transformation) [SNOMED CT concept]
- Transformer (physical object) [SNOMED CT concept]
- b transformation [OBI concept]
- s transformation [OBI concept]
- transformation [IUPAC Term]
- transformer [EFMI term]
Currated CISMeF NLP mapping
- Transformation, function (observable entity) [SNOMED CT concept]
- transformation, nos [SNOMED Notion]
False automatic mappings
- transformation [IUPAC Term]
Semantic type(s)
- Pathologic Function [UMLS semantic type]
biological_process_involves_gene_product
- EBV Secreted Protein BARF1 [NCIt concept]
biological_process_is_part_of_process
- Tumorigenesis [NCIt concept]
process_involves_gene
- EBV BARF1 Gene [NCIt concept]
- HHCM Gene [NCIt concept]
- TRERF1 Gene [NCIt concept]
- TRERF1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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