Preferred Label : Alpha V Beta 8 Antagonist PF-06940434;
NCIt synonyms : Alpha V Beta 8 Inhibitor PF-06940434;
NCIt definition : An antagonist of integrin alpha v beta 8, with potential antineoplastic activity.
Upon administration, PF-06940434 selectively binds to and blocks the receptor for
integrin alpha v beta 8, thereby preventing integrin alpha v beta 8 binding. This
may result in the inhibition of cell adhesion in the tumor microenvironment (TME)
and blocks the activation of the cytokine transforming growth factor-beta 1 (TGF-b1),
preventing TGF-b1-mediated signal transduction. This abrogates TGF-b1-mediated immunosuppression,
enhances anti-tumor immunity in the TME and promotes a cytotoxic T-lymphocyte (CTL)-mediated
immune response against tumor cells leading to tumor cell death. This may lead to
a reduction in TGF-b1-dependent proliferation of cancer cells. Alpha v beta 8 integrin
plays a key role in tumor initiation, growth, and progression through TGF-b1 activation.
It is expressed in a variety of tumor cell types and is associated with poor prognosis.;
Molecule name : PF 06940434; PF-06940434;
NCI Metathesaurus CUI : CL1406223;
Origin ID : C172097;
UMLS CUI : C5417889;
Semantic type(s)
- concept_is_in_subset
- has_target
