NCIt definition : A humanized agonistic monoclonal antibody targeting the cell surface antigen CD27,
with potential immunostimulatory and antineoplastic activities. Upon administration,
boserolimab targets and binds to CD27 on a variety of immune cell types, including
most T-lymphocytes. This induces CD27-dependent signaling pathways and enhances T-cell-mediated
responses, including the expansion of antigen-activated T-cells and the cytotoxic
T-lymphocyte (CTL)-mediated immune response against tumor cells. CD27, a co-stimulatory
molecule and member of the tumor necrosis factor receptor superfamily (TNFRSF), is
expressed on T-lymphocytes, memory B-cells and natural killer (NK) cells. It plays
an important role in NK cell-mediated cytolytic activity and T- and B-lymphocyte proliferation
and activation. It is overexpressed in certain tumor cell types.;
Semantic type(s)