Preferred Label : Brensocatib;
NCIt definition : An orally bioavailable, small molecule, reversible inhibitor of dipeptidyl peptidase
1 (DPP1), with potential anti-inflammatory activity. Upon oral administration, brensocatib
reversibly binds to and inhibits the activity of DPP1, thereby inhibiting the activation
of neutrophil serine proteases (NSPs), including neutrophil elastase (NE), during
neutrophil maturation. This inhibits the activity of NSPs, and may prevent lung inflammation
and injury and improve lung function associated with NSPs-induced respiratory diseases.
NSPs, serine proteases released by neutrophils during inflammation, is upregulated
in a number of respiratory diseases.;
UNII : 25CG88L0BB;
InChIKey : AEXFXNFMSAAELR-RXVVDRJESA-N;
CAS number : 1802148-05-5;
Molecule name : INS 1007; INS-1007; AZD 7986; AZD-7986;
NCI Metathesaurus CUI : CL1405968;
Origin ID : C171778;
UMLS CUI : C5242458;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
