" /> Asciminib Hydrochloride - CISMeF





Preferred Label : Asciminib Hydrochloride;

NCIt synonyms : N-[4-(Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-3-yl)pyridine-3-carboxamidehydrogen Chloride (1/1);

NCIt definition : The hydrochloride salt form of asciminib, an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both wild-type Bcr-Abl and certain mutation forms, including the T315I mutation. This binding results in the inhibition of Bcr-Abl1-mediated proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph ) hematological malignancies. The Bcr-Abl1 fusion protein tyrosine kinase is an abnormal enzyme produced by leukemia cells that contain the Philadelphia chromosome.;

UNII : C5U34S9XFV;

InChIKey : HGCOOPLEWPBLOY-PFEQFJNWSA-N;

CAS number : 2119669-71-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2119669-71-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Scemblix;

Molecule name : ABL001-AAA;

NCI Metathesaurus CUI : CL1405685;

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10/06/2024


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