NCIt definition : The hydrochloride salt form of asciminib, an orally bioavailable, allosteric Bcr-Abl1
tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib
targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location
that is distinct from the ATP-binding domain, thereby inhibiting the activity of both
wild-type Bcr-Abl and certain mutation forms, including the T315I mutation. This binding
results in the inhibition of Bcr-Abl1-mediated proliferation and enhanced apoptosis
of Philadelphia chromosome-positive (Ph ) hematological malignancies. The Bcr-Abl1
fusion protein tyrosine kinase is an abnormal enzyme produced by leukemia cells that
contain the Philadelphia chromosome.;