NCIt definition : An orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic
activity. Upon administration, asciminib targets and binds to the myristoyl pocket
of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding
domain, thereby inhibiting the activity of both wild-type Bcr-Abl and certain mutation
forms, including the T315I mutation. This binding results in the inhibition of Bcr-Abl1-mediated
proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph ) hematological
malignancies. The Bcr-Abl1 fusion protein tyrosine kinase is an abnormal enzyme produced
by leukemia cells that contain the Philadelphia chromosome.;
UNII : L1F3R18W77;
InChIKey : VOVZXURTCKPRDQ-CQSZACIVSA-N;
CAS number : 1492952-76-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1492952-76-7
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