" /> Asciminib - CISMeF





Preferred Label : Asciminib;

NCIt definition : An orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both wild-type Bcr-Abl and certain mutation forms, including the T315I mutation. This binding results in the inhibition of Bcr-Abl1-mediated proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph ) hematological malignancies. The Bcr-Abl1 fusion protein tyrosine kinase is an abnormal enzyme produced by leukemia cells that contain the Philadelphia chromosome.;

UNII : L1F3R18W77;

InChIKey : VOVZXURTCKPRDQ-CQSZACIVSA-N;

CAS number : 1492952-76-7;

Molecule name : ABL-001; ABL 001;

NCI Metathesaurus CUI : CL472320;

Codes from synonyms : 53780;

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01/06/2025


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