" /> Irofulven - CISMeF





Preferred Label : Irofulven;

NCIt synonyms : Hydroxymethylacylfulvene; (R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-one; HMAF;

NCIt related terms : 6-Hydroxymethylacylfulvene;

NCIt definition : A semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and protein macromolecules, forms adducts, and arrests cells in the S-phase of the cell cycle. This agent requires NADPH-dependent metabolism by alkenal/one oxidoreductase for activity. Irofulven is more active in vitro against tumor cells of epithelial origin and is more resistant to deactivation by p53 loss and MDR1 than other alkylating agents. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Irofulven attaches to the cell's DNA and may block cancer cell growth. It is a type of alkylating agent.;

UNII : 6B799IH05A;

InChIKey : NICJCIQSJJKZAH-AWEZNQCLSA-N;

CAS number : 158440-71-2;

Molecule name : MGI-114; MGI 114;

Chemical formula : C15H18O3;

NSC code : 683863;

Codes from synonyms : 50542; NSC0683863; CDR0000043967; CDR0000046045;

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11/05/2025


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