Irofulven - CISMeF

Preferred Label : Irofulven;

NCIt synonyms : Hydroxymethylacylfulvene; (R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-one; HMAF;

NCIt related terms : 6-Hydroxymethylacylfulvene;

NCIt definition : A semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and protein macromolecules, forms adducts, and arrests cells in the S-phase of the cell cycle. This agent requires NADPH-dependent metabolism by alkenal/one oxidoreductase for activity. Irofulven is more active in vitro against tumor cells of epithelial origin and is more resistant to deactivation by p53 loss and MDR1 than other alkylating agents. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Irofulven attaches to the cell's DNA and may block cancer cell growth. It is a type of alkylating agent.;

UNII : 6B799IH05A;

InChIKey : NICJCIQSJJKZAH-AWEZNQCLSA-N;

CAS number : 158440-71-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 158440-71-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MGI-114; MGI 114;

Chemical formula : C15H18O3;

NSC code : 683863;

Codes from synonyms : 50542; NSC0683863; CDR0000043967; CDR0000046045;

Details

Origin ID

C1717;

UMLS CUI

C0532362;

Currated CISMeF NLP mapping
- irofulven [MeSH concept]
- irofulven [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- irofulven [MeSH concept]
- irofulven [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- DNA Alkylation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- DNA Strand Break [NCIt concept]
- Negative Regulation of S Phase [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA [NCIt concept]

Keyword's position in hierarchy(ies) :

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