Preferred Label : MDM2 Inhibitor AMGMDS3;
NCIt synonyms : 2-[(2S,3R,4S)-2,3-bis(3-chlorophenyl)-1-[(2S)-1-ethoxy-1-oxobutan-2-yl]-4-methyl-6-oxopiperidin-4-yl]acetic
Acid;
NCIt definition : An inhibitor of MDM2 (murine double minute 2), with potential antineoplastic activity.
Upon administration, MDM2 inhibitor AMGMDS3 binds to the MDM2 protein and prevents
its binding to the transcriptional activation domain of the tumor suppressor protein
p53. By preventing this MDM2-p53 interaction, the transcriptional activity of p53
is restored. This leads to p53-mediated induction of tumor cell apoptosis. MDM2, a
zinc finger protein and a negative regulator of the p53 pathway, is overexpressed
in cancer cells; it plays a key role in cancer cell proliferation and survival.;
Molecule name : Q59770979; AMGMDS3;
NCI Metathesaurus CUI : CL1405838;
Origin ID : C171616;
UMLS CUI : C5417873;
Semantic type(s)
- concept_is_in_subset
- has_target
