Preferred Label : Copper Cu 67 Ucasareotide Dasaroxetan;
NCIt synonyms : 67Cu-labeled MeCOSar-Tyr3-octreotate; Copper Cu 67 TATE; Copper Cu 67-SARTATE; Cu-67 SARTATE; 67Cu-SARTATE; Copper 67 SARTATE; Copper Cu 67 Tyr3-octreotate; Ucasareotide Dasaroxetan Cu-67;
NCIt definition : A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate
(TATE) conjugated with the bifunctional chelator 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic
acid (MeCOSar) and radiolabeled with the beta-emitting radioisotope copper Cu 67,
with potential antineoplastic activity. Upon administration, copper Cu 67 ucasareotide
dasaroxetan binds to somatostatin receptors (SSTRs), with high affinity to type 2
SSTR, present on the cell membranes of many types of neuroendocrine tumor (NET) cells.
Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic
dose of beta radiation to SSTR-positive cells. TATE is an octreotide derivative in
which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol
is replaced with threonine. SSTRs have been shown to be present in large numbers on
NET and their metastases, while most other normal tissues express low levels of SSTRs.;
UNII : Y6WKJ2X9X8;
NCI Metathesaurus CUI : CL1405493;
Origin ID : C171370;
UMLS CUI : C5419110;
Semantic type(s)
- concept_is_in_subset
- has_target
