Preferred Label : Anti-EGFR/CD16A Bispecific Antibody AFM24;
NCIt synonyms : Bispecific EGFR/CD16A Innate Cell Engager AFM24; Anti-EGFR/CD16A Tetravalent Bispecific Antibody AFM24; Anti-EGFR/Anti-CD16A Bispecific Antibody AFM24;
NCIt definition : A human, tetravalent, bispecific antibody targeting both the epidermal growth factor
receptor (EGFR) and the human low affinity IgG Fc region receptor IIIA (FCGR3A; CD16A),
with potential immunomodulating and antineoplastic activities. Upon administration,
anti-EGFR/CD16A bispecific antibody AFM24 simultaneously targets and binds to the
CD16A expressed on natural killer (NK) cells and macrophages, and to EGFR on EGFR-expressing
tumor cells, thereby selectively cross-linking EGFR-expressing tumor cells with NK
cells and macrophages. This may result in NK cell and macrophage activation, antibody-dependent
cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and
eventually tumor cell lysis. EGFR, a receptor tyrosine kinase upregulated or mutated
in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
CD16A is specifically expressed on the surface of NK cells and macrophages.;
Molecule name : AFM-24; AFM 24;
NCI Metathesaurus CUI : CL1405396;
Origin ID : C171163;
UMLS CUI : C5417850;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
