Preferred Label : Tuvusertib;
NCIt synonyms : ATR Kinase Inhibitor M1774;
NCIt definition : An orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase,
with potential antineoplastic activity. Upon oral administration, tuvusertib selectively
inhibits ATR activity and blocks the downstream phosphorylation of the serine/threonine
protein kinase checkpoint kinase 1 (CHK1). This prevents ATR-mediated signaling, which
results in the inhibition of DNA damage checkpoint activation, the disruption of DNA
damage repair, and the induction of tumor cell apoptosis. ATR, a serine/threonine
protein kinase upregulated in a variety of cancer cell types, plays a key role in
DNA repair, cell cycle progression and survival. It is activated by DNA damage caused
during DNA replication-associated stress.;
UNII : JE1BE6ZGZ7;
Molecule name : M-1774; M 1774;
NCI Metathesaurus CUI : CL1405453;
Origin ID : C171067;
UMLS CUI : C5706667;
Semantic type(s)
- concept_is_in_subset
- has_target
