NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting the co-inhibitory
molecule and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin
(Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with
potential immune checkpoint inhibitory activity. Upon administration, ociperlimab
targets and binds to TIGIT expressed on various immune cells, particularly on tumor-infiltrating
T-lymphocytes (TILs), thereby preventing the interaction of TIGIT with its ligands
CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2) and CD155 (poliovirus
receptor; PVR; nectin-like protein 5; NECL-5). This enhances the interaction of CD112
and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1),
which is expressed on immune cells, such as natural killer (NK) cells and CD8 T-cells.
This leads to CD226 dimerization and CD226-mediated signaling and activates the immune
system to exert a T-cell-mediated immune response against cancer cells. TIGIT, a member
of the Ig super family (IgSF) and an immune inhibitory receptor, plays a key role
in the suppression of T-cell proliferation and activation; it is involved in tumor
cell immune evasion, and the inhibition of antiviral immune responses.;
Semantic type(s)