Preferred Label : iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596;
NCIt synonyms : iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-Natural Killer Cells FT596; Induced Pluripotent Stem Cell-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells
FT596;
NCIt definition : An allogeneic, off-the-shelf, chimeric antigen receptor (CAR)-natural killer (NK)
cell product derived from a clonal master induced pluripotent stem cell (iPSC) line,
and engineered to express a NK cell-specific anti-CD19 CAR, a high-affinity, non-cleavable
CD16 (hnCD16) Fc receptor, and a recombinant fusion of IL-15 and IL-15 receptor alpha
(IL-15RF), with potential immunostimulatory and antineoplastic activities. Upon administration,
iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596 recognize, bind
to and induce selective cytotoxicity in CD19-expressing tumor cells. IL-15RF enhances
the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. When used
in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT596 binds to
the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation,
cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD19
antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage
malignancies. CD16, also known as Fc-gamma receptor III, is normally expressed on
the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role
in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting
the anti-tumor immune response.;
Molecule name : FT 596; FT-596;
NCI Metathesaurus CUI : CL1383208;
Origin ID : C170800;
UMLS CUI : C5417817;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
